Searchable abstracts of presentations at key conferences in endocrinology

ea0011p813 | Thyroid | ECE2006

Liver enzymes alterations during high dose intravenous glucocorticoid pulse therapy for graves’ ophthalmopathy: frequency and putative risk factors

Altea MA , Morabito E , Menconi F , Piccione R , Latrofa F , Mazzi B , Bartalena L , Pinchera A , Marcocci C , Marinò M

Recently, we have reported a few cases of acute liver damage in patients with Graves’ ophthalmopathy (GO), during or following high dose intravenous (iv) glucocorticoid (GC) pulse therapy. In the present study we analyzed retrospectively liver enzymes (LE) in 294 consecutive patients with GO who underwent ivGC. LE were measured before or during ivGC, and in 91 patients also within 6 months after ivGC. An asymptomatic increase in LE (AST peak: 67–88 U/L, ALT peak: 75&...